Kinetics of (+)-tubocurarine blockade at the neuromuscular junction
نویسندگان
چکیده
منابع مشابه
The actions of tubocurarine at the frog neuromuscular junction.
1. The action of tubocurarine on voltage-clamped frog muscle end-plates has been re-examined by means (a) equilibrium dose-ratio measurements, (b) current fluctuation measurements and (c) voltage-jump relaxation measurements. 2. The equilibrium measurements can be interpreted as implying that tubocurarine has (a) a competitive blocking action, with a dissociation constant of 0.34 microM, which ...
متن کاملReappearance of the train-of-four after neuromuscular blockade induced with tubocurarine, vecuronium or atracurium.
The characteristics of train-of-four recovery after atracurium or vecuronium were studied, under enflurane anaesthesia, and compared with those associated with tubocurarine-induced blockade. Ten patients each received vecuronium 0.1 mg kg-1, atracurium 0.5 mg kg-1 or tubocurarine 0.5 mg kg-1. Neuromuscular blockade was calculated as the percent depression of the first twitch, and was determined...
متن کاملRelation between subsynaptic receptor blockade and response to quantal transmitter at the mouse neuromuscular junction
When a quantum of transmitter is released into a synaptic cleft, the magnitude of the subsynaptic response depends upon how much transmitter becomes bound to receptors. Theoretical considerations lead to the conclusion that if receptor density is normally high enough that most of the quantal transmitter is captured, subsynaptic quantal responses may be insensitive to receptor blockade. The effe...
متن کاملN-CAM at the vertebrate neuromuscular junction
We have detected the neural cell adhesion molecule, N-CAM, at nerve-muscle contacts in the developing and adult mouse diaphragm. Whereas we found N-CAM staining with fluorescent antibodies consistently to overlap with the pattern of alpha-bungarotoxin staining at nerve-muscle contacts both during development and in the adult, we observed N-CAM staining on the surfaces of developing myofibers an...
متن کاملTransmitter release at the neuromuscular junction.
NATIONAL REVIEW OF 105 OBIOLOGY, VOL. 75 Copyright 2006, Elsev All rights re 0.1016/S0074-7742(06)75006-1 0074-7742/06 II. P hysiological Properties of Transmitter Release III. E xperimental Advantages and Limitations of the Fly NMJ A. C a2þ Measurements B. D ye Loading C. A lternative Measures of Exocytosis IV. H ow Do Vesicles Fuse: Full Fusion or Kiss-and-Run? V. C ore Machinery of Exocytosi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1991
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1991.tb09835.x